Identification of transcription factors binding motif in eukaryotic genomes

Lucia Nikolaia López Bojorquez, Ph.D.
Identifying genomic location of transcription factor binding sites, mainly in higher eukaryotic genomes, has been an great challenge. Different experimental and computational approaches, has been used to identify these sites, methods involving computational comparisons of related genomes have been particularly successful. In this regard Bioinformatic approach to transcriptional regulation is a relatively new study area. The current project is about the identification of the potential target genes of transcription factor TTF-1/NKX2.1 in metazoan genomes. This project has implications over Central Nervous System and Hypothalamic-Hypophysis-Thyroid axis development.